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Metal Exposure in the Children of Punjab, India- MTM Study published in Clinical Medicine Insights: Therapeutics

Our test results documented that hair and urine mineral analysis results support each other. This is of interest, because hair evaluates past exposure while the analysis of baseline urine detects immediate exposure. Furthermore, we could document that our test group of 114 children show evidence of past and present exposure to one or more of the metals tested. A DMSA challenge test was effective in detoxifying lead.

Read the abstract and download the article:

http://bit.ly/apqBcj

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Chelation Corner: Chelating Iron in Conditions of Iron Overload (Hemochromatosis)

by E. Blaurock-Busch, PhD

http://www.townsendletter.com/May2009/chelation0509.htm

We have tested hair samples of a total of 149 people of Punjab, India. Of those 116 were children 12years and younger; 33 were 13years and older. The hair results are somewhat surprising. We expected an arsenic exposure, but did not. Instead, over 80 percent of the adults and the children, many of which are suffering from Cerebral Palsy and Mental Retardation showed pathological levels for uranium, indicating high tissue levels.

More soon.

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Update on Mercury in Amalgams:

http://www.medscape.com/viewarticle/577710

Interestingly, this FDA article states 'The group calls for blood or urine tests or hair analysis to detect mercury levels in the body, removal of amalgam fillings (except from pregnant women), and replacement of these fillings with composite (plastic) fillings, followed by oral chelation therapy to remove residual levels of mercury.'

Blood Levels of Mercury Are Related to Diagnosis of Autism: A Reanalysis of an Important Data Set

M. Catherine DeSoto, PhD Department of Psychology, University of Northern Iowa, Cedar Falls, Iowa,

Robert T. Hitlan, PhD Department of Psychology, University of Northern Iowa, Cedar Falls, Iowa

The question of what is leading to the apparent increase in autism is of great importance. Like the link between aspirin and heart attack, even a small effect can have major health implications. If there is any link between autism and mercury, it is absolutely crucial that the first reports of the question are not falsely stating that no link occurs. We have reanalyzed the data set originally reported by Ip et al. in 2004 and have found that the original p value was in error and that a significant relation does exist between the blood levels of mercury and diagnosis of an autism spectrum disorder. Moreover, the hair sample analysis results offer some support for the idea that persons with autism may be less efficient and more variable at eliminating mercury from the blood.

Key Words: autism • mercury • environmental health • neuro-toxin • neurodevelopment • blood

 

Elemental anomalies in hair as indicators of endocrinologic pathologies and deficiencies in calcium and bone metabolism

Miekeley N, de Fortes Carvalho LM, Porto da Silveira Cl, Lima MB

Department of Chemistry, Pontifical Catholic University, Rio de Janeiro, Brazil. J Trace Elem Med Biol. 2001;15(1):46-55

Analytical results obtained by ICP-MS of hair samples from a group of women from Rio de Janeiro city show that abnormal Ca and P concentrations in this compartment can be an indication of pathologies affecting the metabolism of these elements. The study was conducted initially on 900 women (outpatients, >40 years). From this group, approx. 24% showed anomalously high or low Ca concentrations in hair, in some cases correlated to anomalies of other elements. In 144 cases (16%), very high concentrations of Ca (up to 8,285 mg/kg) were measured, frequently correlated with a high concentration of P (up to 4,720 mg/kg), exceeding by far the reference intervals for this age/sex group. Follow-up studies of a few individuals from this group gave first indications that their abnormal hair compositions were related to endocrinologic pathologies affecting calcium/bone metabolism. Very low hair Ca-concentrations were observed in older women (72 cases, age >60 years) and related to senile osteoporosis. Complementary investigations of patients with recognized endocrinologic pathologies (hyperthyroidism, hyper- and hypoparathyroidism) and osteomalacia gave statistical support for the hypothesis that hair concentrations of Ca, P and various other trace elements are influenced characteristically by these diseases. In patients with hyperparathyroidism and hyperthyroidism, both elements showed significant increase in hair, whereas patients with rickets/osteomalacia had only elevated Ca concentrations, together with suspiciously high toxic levels of Cd and various other elements (Fe, Mn, Mg, Sr, Ba). Patients with hypoparathyroidism had significantly decreased Ca and P concentrations in hair. Statistical evaluation of these data by multivariant analysis (MANOVA) using a contrast matrix and by discriminant analysis showed that elemental hair anomalies can be used to diagnose correctly the above-mentioned pathologies, demonstrating the usefulness of hair analysis as a complementary tool for the detection of disturbances in calcium/bone metabolism.

Arsenic in Bangladesh drinking water

Uranium and cell damage

Research Summary 

In 10 healthy male students serum creatinine and endogenous creatinine clearance were estimated during maximal exercise. Serum creatinine levels rose significantly. This was due not only to the well known decrease of creatinine clearance during maximal exercise but also to mobilisation of creatinine from the working muscle. Conclusions concerning glomerular filtration rate should therefore not be drawn from serum creatinine during exercise.

W. Hallauer, J. Staiger und J. SchirmeisterKreatinin in Serum und Harn unter maximaler körperlicher Belastung. Journal of Molecular Medicine Vol50, Nr4, 197

Urine Creatinine in post chelation or provocation urine:

During chelation, the urine creatinine concentration falls below the baseline value. Kidney stress or dehydration causes the urine creatinine concentration to stay at the baseline level, or depending on the kidney stress, rises above the baseline level. This indicates a need to check kidney function with a serum creatinine test.

We statistically evaluated the urine creatinine levels of post chelation urines of 4018 patients, 12 years and older. The mean value was 0.5g/L creatinine. The 2 Standard Deviation value was <0.2 to 1.5g/L creatinine.  The evaluation of 101 children, age <12years of age provided a mean value of 0.5g/L creatinine with a Standard Deviation Range of <0.2 to 1.2g/L creatinine.